Article

Genetic regulation of DNA methylation across tissues reveals thousands of molecular links to complex traits

2021-05-11

Abstract excerpt

<title>Abstract</title> <p>Epigenetic modifications of chromosomes, including DNA methylation (DNAm), play a fundamental role in gene regulation in humans. We generated DNAm data for 987 samples from the Genotype-Tissue Expression (GTEx) project, representing 9 tissue types and 424 subjects. We integrated GTEx RNA-seq data to examine methylome-transcriptome associations, their tissue specificity, and their overla...

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Literature Corpus work: 7c32a037-6e9b-567c-bf4e-6804e91a0c40
DOI: 10.21203/rs.3.rs-492596/v1

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