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Article

xQTLatlas: a comprehensive resource for human cellular-resolution multi-omics genetic regulatory landscape.

Nucleic acids research - 6 Jan 2025

Jia Yuran, Dong Hongchao, Li Linhao, Wang Fang, Juan Liran, Wang Yadong, Guo Hongzhe, Zhao Tianyi

Abstract excerpt

Understanding how genetic variants influence molecular phenotypes in different cellular contexts is crucial for elucidating the molecular and cellular mechanisms behind complex traits, which in turn has spurred significant advances in research into molecular quantitative trait locus (xQTL) at the cellular level. With the rapid proliferation of data, there is a critical need for a comprehensive and accessible...

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PMID: 39351883
DOI: 10.1093/nar/gkae837
PMCID: PMC11701524

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xQTLatlas: a comprehensive resource for human cellular-resolution multi-omics genetic regulatory landscape.PMID 39351883Read ↗

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Integrative analysis of 10,000 epigenomic maps across 800 samples for regulatory genomics and disease dissectionSemantic proximity Read ↗

TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies.Semantic proximity Read ↗

MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants.Semantic proximity Read ↗

Airqtl dissects cell state-specific causal gene regulatory networks with efficient single-cell eQTL mappingSemantic proximity Read ↗

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