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Chromatin accessibility landscape of articular knee cartilage reveals aberrant enhancer regulation in osteoarthritis

15 Oct 2018

Abstract excerpt

Osteoarthritis (OA) is a common joint disorder with increasing impact in an aging society. While genetic and transcriptomic analyses have revealed some genes and non-coding loci associated to OA, the pathogenesis remains incompletely understood. Chromatin profiling, which provides insight into gene regulation, has not been reported in OA mainly due to technical difficulties. Here, we employed Assay for...

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PMID: 30341348
DOI: 10.1038/s41598-018-33779-z

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