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Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population.

Communications biology - 9 Sept 2021

Wu Chia-Hsin, Hsieh Chia-Shan, Chang Yo-Cheng, Huang Chi-Cheng, Yeh Hsien-Tang, Hou Ming-Feng, Chung Yuan-Chiang, Tu Shih-Hsin, Chang King-Jen, Chattopadhyay Amrita, Lai Liang-Chuan, Lu Tzu-Pin, Li Yung-Hua, Tsai Mong-Hsun, Chuang Eric Y

Abstract excerpt

Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis of WGD and its influence on breast cancer subtypes in patients from Taiwan and consequently highlight the genomic association between WGD and...

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Identifiers

PMID: 34504292
DOI: 10.1038/s42003-021-02597-x
PMCID: PMC8429690

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