Article
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer.
Nature - 1 Aug 2025
McPherson Andrew, Vázquez-García Ignacio, Myers Matthew A, Al-Rawi Duaa H, Zatzman Matthew, Weiner Adam C, Freeman Samuel, Mohibullah Neeman, Satas Gryte, Williams Marc J, Ceglia Nicholas, Norkūnaitė Danguolė, Zhang Allen W, Li Jun, Lim Jamie L P, Wu Michelle, Choi Seongmin, Havasov Eliyahu, Grewal Diljot, Shi Hongyu, Kim Minsoo, Schwarz Roland F, Kaufmann Tom, Dinh Khanh Ngoc, Uhlitz Florian, Tran Julie, Wu Yushi, Patel Ruchi, Ramakrishnan Satish, Kim DooA, Clarke Justin, Green Hunter, Ali Emily, DiBona Melody, Varice Nancy, Kundra Ritika, Broach Vance, Gardner Ginger J, Roche Kara Long, Sonoda Yukio, Zivanovic Oliver, Kim Sarah H, Grisham Rachel N, Liu Ying L, Viale Agnes, Rusk Nicole, Lakhman Yulia, Ellenson Lora H, Tavaré Simon, Aparicio Samuel, Chi Dennis S, Aghajanian Carol, Abu-Rustum Nadeem R, Friedman Claire F, Zamarin Dmitriy, Weigelt Britta, Bakhoum Samuel F, Shah Sohrab P
Abstract excerpt
Whole-genome doubling (WGD) is a common feature of human cancers and is linked to tumour progression, drug resistance, and metastasis1-6. Here we examine the impact of WGD on somatic evolution and immune evasion at single-cell resolution in patient tumours. Using single-cell whole-genome sequencing, we analysed 70 high-grade serous ovarian cancer samples from 41 patients (30,260 tumour genomes) and observed...
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