Pan-cancer proteogenomic landscape of whole-genome doubling reveals putative therapeutic targets in various cancer types

Abstract excerpt

<h4>Background</h4> Whole-genome doubling (WGD) is prevalent in cancer and drives tumor development and chromosomal instability. Driver mutations in mitotic cell cycle genes and cell cycle upregulation have been reported as the major molecular underpinnings of WGD tumors. However, the underlying genomic signatures and regulatory networks involved in gene transcription and kinase phosphorylation remain unclear. Her...

Topics

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• Cancer Genomics and Diagnostics
• Cancer-related gene regulation
• Cancer-related Molecular Pathways
• Genetic factors in colorectal cancer
• Genome, Human
• Microtubule and mitosis dynamics
• Mutation
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

392dd588-e79b-54db-93ea-8b058721d511

DOI

10.1101/2024.04.16.24305805