Article
Pan-cancer analysis of whole-genome doubling and its association with patient prognosis.
BMC cancer - 3 Jul 2023
Kikutake Chie, Suyama Mikita
Abstract excerpt
BACKGROUND: Whole-genome doubling (WGD) is a common mutation in cancer. Various studies have suggested that WGD is associated with a poor prognosis in cancer. However, the detailed association between WGD occurrence and prognosis remains unclear. In this study, we aimed to elucidate the mechanism by which WGD affects prognosis using sequencing data from the Pan-Cancer Analysis of Whole Genomes (PCAWG) and The...
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