Article
Genome doubling shapes the evolution and prognosis of advanced cancers.
Nature genetics - 1 Aug 2018
Bielski Craig M, Zehir Ahmet, Penson Alexander V, Donoghue Mark T A, Chatila Walid, Armenia Joshua, Chang Matthew T, Schram Alison M, Jonsson Philip, Bandlamudi Chaitanya, Razavi Pedram, Iyer Gopa, Robson Mark E, Stadler Zsofia K, Schultz Nikolaus, Baselga Jose, Solit David B, Hyman David M, Berger Michael F, Taylor Barry S
Abstract excerpt
Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients. WGD varied by tumor lineage and molecular subtype, and arose early in carcinogenesis after an antecedent transforming driver mutation. While associated with TP53...
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