Article

Whole-genome duplication shapes the aneuploidy landscape of human cancers

2021-05-05

Abstract excerpt

Aneuploidy – a hallmark of cancer – has tissue-specific recurrence patterns suggesting it plays a driving role in cancer initiation and progression. However, the contribution of aneuploidy to tumorigenesis depends on the cellular and genomic context in which it arises. Whole-genome duplication (WGD) is a common macro-evolutionary event that occurs in >25% of human tumors during the early stages of tumorigenesis. A...

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Literature Corpus work: 4fe74642-1708-5bfc-9800-5f88321ac4a6
DOI: 10.1101/2021.05.05.442712

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