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Article

Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons.

BMC neuroscience - 4 Mar 2024

Heider Johanna, Stahl Aaron, Sperlich Denise, Hartmann Sophia-Marie, Vogel Sabrina, Breitmeyer Ricarda, Templin Markus, Volkmer Hansjürgen

Abstract excerpt

BACKGROUND: Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previous studies have mainly used animal models or rather heterogeneous populations of iPSC-derived neurons, generated by...

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Identifiers

PMID: 38438989
DOI: 10.1186/s12868-024-00858-z
PMCID: PMC10910844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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