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Article

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

11 Apr 2018

Abstract excerpt

The development of three-dimensional culture methods has allowed for the study of developing cortical morphology in human cells. This provides a new tool to study the neurodevelopmental consequences of disease-associated mutations. Here, we study the effects of isogenic DISC1 mutation in cerebral organoids. DISC1 has been implicated in psychiatric disease based on genetic studies, including its interruption by a...

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PMID: 29643329
DOI: 10.1038/s41398-018-0122-x

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