Article
Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation.
Nature communications - 3 Mar 2021
Kim Nam-Shik, Wen Zhexing, Liu Jing, Zhou Ying, Guo Ziyuan, Xu Chongchong, Lin Yu-Ting, Yoon Ki-Jun, Park Junhyun, Cho Michelle, Kim Minji, Wang Xinyuan, Yu Huimei, Sakamuru Srilatha, Christian Kimberly M, Hsu Kuei-Sen, Xia Menghang, Li Weidong, Ross Christopher A, Margolis Russell L, Lu Xin-Yun, Song Hongjun, Ming Guo-Li
Abstract excerpt
We previously identified a causal link between a rare patient mutation in DISC1 (disrupted-in-schizophrenia 1) and synaptic deficits in cortical neurons differentiated from isogenic patient-derived induced pluripotent stem cells (iPSCs). Here we find that transcripts related to phosphodiesterase 4 (PDE4) signaling are significantly elevated in human cortical neurons differentiated from iPSCs with the DISC1...
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