Article

Development of a Disease Modeling Framework for Glutamatergic Neurons Derived from Neuroblastoma Cells in 3D Microarrays

2024-09-27

Abstract excerpt

<title>Abstract</title> <p>Neurodegenerative diseases (NDDs) present significant challenges due to limited treatment options and the ethical concerns of traditional animal models and iPSC-derived neurons. We addressed these issues by developing a 3D culture protocol for differentiating SH-SY5Y cells into glutamatergic neurons, enhancing physiological relevance with a 3D microarray culture plate. Our protocol opti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9be5511c-78e3-55fb-8a30-c74e72b13dc5
DOI: 10.21203/rs.3.rs-4934775/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of a Disease Modeling Framework for Glutamatergic Neurons Derived from Neuroblastoma Cells in 3D MicroarraysDOI 10.21203/rs.3.rs-4934775/v1Read

A Novel and Robust Protocol for Differentiation of SH-SY5Y Neuroblastoma Cells into Neuron Like CellsSemantic proximity Read

Methods used to achieve different levels of the neuronal differentiation process in SH‐SY5Y and Neuro2a cell lines: An integrative reviewSemantic proximity Read

Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-cultureSemantic proximity Read

The role of neuron-like cell lines and primary neuron cell models in unraveling the complexity of neurodegenerative diseases: a comprehensive reviewSemantic proximity Read

A multi-omics approach to visualize early neuronal differentiation in 4DSemantic proximity Read

Robust and reproducible neuronal differentiation of human embryonic stem cells for neurotoxicologySemantic proximity Read

Complementary 2D and 3D cultures deriving from a single human cortical differentiation process recapitulate in vitro neurodevelopmental and neurogenerative features of juvenile Huntington’s DiseaseSemantic proximity Read

GluN2A-mediated currents and calcium signal in human iPSC-derived neuronsSemantic proximity Read

The BE (2)-M17 neuroblastoma cell line: revealing its potential as a cellular model for Parkinson’s diseaseSemantic proximity Read

Differentiation of the SH-SY5Y Human Neuroblastoma Cell LineSemantic proximity Read

Deciphering the protein dynamics and molecular determinants of iPSC-derived neuronsSemantic proximity Read