Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A co-culture model of dopaminergic and glutamatergic neurons derived from patients with idiopathic schizophrenia reveals a hypodopaminergic phenotype.

Molecular psychiatry - 1 Apr 2026

Hartmann Sophia-Marie, Pizarro Garcia Patricia, Heider Johanna, Vogel Sabrina, Wüstner Lisa-Sophie, Wüst Richard, Fallgatter Andreas J, Volkmer Hansjürgen

Abstract excerpt

Schizophrenia (SCZ) is a severe neurodevelopmental mental disorder characterised by a complex and multifactorial disease aetiology. Patients can suffer from both positive symptoms (e.g. hallucinations) and negative symptoms (e.g. social withdrawal) as well as cognitive impairments. The former are currently discussed to be caused by a hyperdopaminergic state in the striatum, whereas for the latter a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to Glutamic Acid

Share to Induced Pluripotent Stem Cells

Share to Prefrontal Cortex

Share to Receptors, Dopamine D2

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 41388144
DOI: 10.1038/s41380-025-03384-4
PMCID: PMC12999524

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A co-culture model of dopaminergic and glutamatergic neurons derived from patients with idiopathic schizophrenia reveals a hypodopaminergic phenotype.PMID 41388144Read ↗

Modelling schizophrenia using human induced pluripotent stem cells.Semantic proximity Read ↗

GABAergic neuron dysregulation in a human neurodevelopmental model for major psychiatric disordersSemantic proximity Read ↗

The dopamine hypothesis of schizophrenia: version III--the final common pathway.Semantic proximity Read ↗

Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analysesSemantic proximity Read ↗

iPSC-derived neurons as a tool for probing molecular pharmacology of antipsychotic actionSemantic proximity Read ↗

Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia.Semantic proximity Read ↗

Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling.Semantic proximity Read ↗

Schizophrenia: diverse approaches to a complex disease.Semantic proximity Read ↗

hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic developmentSemantic proximity Read ↗

Patient iPSC-derived astrocytes with high polygenic risk for schizophrenia reveals a role for mitochondrial glutamate carrier SLC25A18Semantic proximity Read ↗

Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in miceSemantic proximity Read ↗

Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophreniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.