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Article

Bone marrow plasma cells require P2RX4 to sense extracellular ATP.

Nature - 1 Feb 2024

Ishikawa Masaki, Hasanali Zainul S, Zhao Yongge, Das Arundhoti, Lavaert Marieke, Roman Carly J, Londregan Jennifer, Allman David, Bhandoola Avinash

Abstract excerpt

Plasma cells produce large quantities of antibodies and so play essential roles in immune protection1. Plasma cells, including a long-lived subset, reside in the bone marrow where they depend on poorly defined microenvironment-linked survival signals1. We show that bone marrow plasma cells use the ligand-gated purinergic ion channel P2RX4 to sense extracellular ATP released by bone marrow osteoblasts through the...

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Source

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Identifiers

PMID: 38355795
DOI: 10.1038/s41586-024-07047-2
PMCID: PMC11025016

Genes

P2RX4
PANX3
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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