Article

Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function

2025-07-18

Abstract excerpt

Engineered plasma cells (ePCs) offer a durable strategy for in vivo delivery of therapeutic antibodies, but standard immunodeficient mouse models lack human immune factors critical for plasma cell survival and function. We utilized a humanized mouse model in which NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice were engrafted with human CD34 + stem cells as recipients for infusions with autologous ePCs. In this...

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Literature Corpus work: 47465445-98e4-521e-9608-a6b46d7d4a83
DOI: 10.1101/2025.07.14.664835

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