Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.

doi:10.2337/db17-1227

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Article

Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.

Diabetes - 1 Oct 2018

Tezza Sara, Ben Nasr Moufida, D'Addio Francesca, Vergani Andrea, Usuelli Vera, Falzoni Simonetta, Bassi Roberto, Dellepiane Sergio, Fotino Carmen, Rossi Chiara, Maestroni Anna, Solini Anna, Corradi Domenico, Giani Elisa, Mameli Chiara, Bertuzzi Federico, Pezzolesi Marcus G, Wasserfall Clive H, Atkinson Mark A, Füchtbauer Ernst-Martin, Ricordi Camillo, Folli Franco, Di Virgilio Francesco, Pileggi Antonello, Dhe-Paganon Sirano, Zuccotti Gian Vincenzo, Fiorina Paolo

Abstract excerpt

Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent an early step in T1D onset. Specifically, we observed that in patients with newly diagnosed T1D, P2X7R is upregulated on CD8+ effector T cells in comparison with healthy control...

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PMID: 30065030
DOI: 10.2337/db17-1227
PMCID: PMC6905486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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