Article
ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism.
Immunity - 20 Nov 2014
Proietti Michele, Cornacchione Vanessa, Rezzonico Jost Tanja, Romagnani Andrea, Faliti Caterina Elisa, Perruzza Lisa, Rigoni Rosita, Radaelli Enrico, Caprioli Flavio, Preziuso Silvia, Brannetti Barbara, Thelen Marcus, McCoy Kathy D, Slack Emma, Traggiai Elisabetta, Grassi Fabio
Abstract excerpt
Microbial colonization of the gut induces the development of gut-associated lymphoid tissue (GALT). The molecular mechanisms that regulate GALT function and result in gut-commensal homeostasis are poorly defined. T follicular helper (Tfh) cells in Peyer's patches (PPs) promote high-affinity IgA responses. Here we found that the ATP-gated ionotropic P2X7 receptor controls Tfh cell numbers in PPs. Lack of P2X7 in...
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