Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.

Journal of cell science - 15 Dec 2015

Adamczyk Magdalena, Griffiths Rhiannon, Dewitt Sharon, Knäuper Vera, Aeschlimann Daniel

Abstract excerpt

Transglutaminases (denoted TG or TGM) are externalized from cells via an unknown unconventional secretory pathway. Here, we show for the first time that purinergic signaling regulates active secretion of TG2 (also known as TGM2), an enzyme with a pivotal role in stabilizing extracellular matrices and modulating cell-matrix interactions in tissue repair. Extracellular ATP promotes TG2 secretion by macrophages, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to GTP-Binding Proteins

Share to Membrane Potentials

Share to Protein Glutamine gamma Glutamyltransferase 2

Share to Receptors, Purinergic P2X7

Share to Transglutaminases

Source

Open in PubMed Open full text

Identifiers

PMID: 26542019
DOI: 10.1242/jcs.175968
PMCID: PMC4696497

Genes

TGM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.PMID 26542019Read ↗

Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions.Semantic proximity Read ↗

Regulation of Immune Response by P2X7 ReceptorSemantic proximity Read ↗

Functional Expression of the P2X7 ATP Receptor Requires Eros.Semantic proximity Read ↗

Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor.Semantic proximity Read ↗

Tissue transglutaminase: from biological glue to cell survival cues.Semantic proximity Read ↗

Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells.Semantic proximity Read ↗

P2RX7 at the Host-Pathogen Interface of Infectious DiseasesSemantic proximity Read ↗

Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.Semantic proximity Read ↗

Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.Semantic proximity Read ↗

Intracellular localization and conformational state of transglutaminase 2: implications for cell death.Semantic proximity Read ↗

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.Semantic proximity Read ↗

Identification and characterization of splice variants of the human P2X7 ATP channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.