Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Expression of the P2X7 ATP Receptor Requires Eros.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2020

Ryoden Yuta, Fujii Toshihiro, Segawa Katsumori, Nagata Shigekazu

Abstract excerpt

In response to extracellular ATP, the purinergic receptor P2X7 mediates various biological processes, including phosphatidylserine (PtdSer) exposure, phospholipid scrambling, dye uptake, ion transport, and IL-1β production. A genome-wide CRISPR screen for molecules responsible for ATP-induced PtdSer exposure identified a transmembrane protein, essential for reactive oxygen species (Eros), as a necessary component...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Calcium Signaling
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-1beta

Share to Phagocytosis

Share to Phosphatidylserines

Share to Receptors, Purinergic P2X7

Share to THP-1 Cells

Source

Identifiers

PMID: 31862710
DOI: 10.4049/jimmunol.1900448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Expression of the P2X7 ATP Receptor Requires Eros.PMID 31862710Read ↗

Regulation of Immune Response by P2X7 ReceptorSemantic proximity Read ↗

Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells.Semantic proximity Read ↗

P2RX7 at the Host-Pathogen Interface of Infectious DiseasesSemantic proximity Read ↗

Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1.Semantic proximity Read ↗

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signallingSemantic proximity Read ↗

P2X7 Variants in PathophysiologySemantic proximity Read ↗

Rat P2X7 Receptor Show Functional Independence Between Macropore Formation and Scavenger Activity.Semantic proximity Read ↗

PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death.Semantic proximity Read ↗

ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survivalSemantic proximity Read ↗

Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potentialSemantic proximity Read ↗

Significance of P2X7 receptor variants to human health and disease.Semantic proximity Read ↗

Loss-of-function/gain-of-function polymorphisms of the ATP sensitive P2X7R influence sepsis, septic shock, pneumonia, and survival outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.