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Article

ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival

7 Aug 2018

Abstract excerpt

The ATP-gated receptor P2X 7 is expressed in multiple malignant tumours including neuroblastoma, melanoma, prostate, lung and breast. P2X 7 has a significant role in mediating diverse cell responses, which upon dysregulation are associated with tumour initiation and development. The rapid, ATP-mediated activation of P2X 7 induces a fast-inward cation current in cells. However, prolonged ATP-mediated activation of...

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PMID: 30087439
DOI: 10.1038/s41388-018-0426-6

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