Identification of Antibodies to DQβ:DRα Interisotypic Heterodimers in Human Sera.

Abstract excerpt

BACKGROUND: HLA class II antigens, DR, DQ, and DP, comprised an α and β chains, which typically combine, within the same isotype, to form the major histocompatibility complex:peptide complex. Interisotypic pairing is not commonly observed. Although reports of DQβ:DRα heterodimers exist, the pairing was reported to be unstable and, therefore, not studied to any extent. METHODS: DQβ:DRα single antigens were...

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• Share to Alleles
• Share to HLA-DQ beta-Chains
• Share to HLA-DR Antigens