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HLA class I peptide polymorphisms contribute to class II DQβ0603:DQα0103 antibody specificity

19 Jan 2024

Abstract excerpt

Antibodies reactive to human leukocyte antigens (HLA) represent a barrier for patients awaiting transplantation. Based on reactivity patterns in single-antigen bead (SAB) assays, various epitope matching algorithms have been proposed to improve transplant outcomes. However, some antibody reactivities cannot be explained by amino acid motifs, leading to uncertainty about their clinical relevance. Antibodies...

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PMID: 38242876
DOI: 10.1038/s41467-024-44912-0

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