HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

Article

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1993

Kwok W W, Kovats S, Thurtle P, Nepom G T

Abstract excerpt

HLA-DQ class II molecules are complex heterodimers in which polymorphic alpha- and beta-polypeptides form noncovalent associations leading to cell surface expression. Using gene transfer with retroviral vectors, we demonstrate that surface expression of heterodimers among various DQ alpha and -be...

Topics

Alleles
Antigens, Surface
Base Sequence
Cell Line
HLA-DQ Antigens
Histocompatibility Antigens Class II
Humans
Molecular Sequence Data
Polymorphism, Genetic
Protein Conformation

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