Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1993

Kwok W W, Kovats S, Thurtle P, Nepom G T

Abstract excerpt

HLA-DQ class II molecules are complex heterodimers in which polymorphic alpha- and beta-polypeptides form noncovalent associations leading to cell surface expression. Using gene transfer with retroviral vectors, we demonstrate that surface expression of heterodimers among various DQ alpha and -beta polypeptides is not universal. Two types of allele-specific constraints were found: DQ beta chains that are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to HLA-DQ Antigens

Share to Molecular Sequence Data

Share to Polymorphism, Genetic

Share to Protein Conformation

Source

Identifiers

PMID: 8450211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.PMID 8450211Read ↗

Identification of Antibodies to DQβ:DRα Interisotypic Heterodimers in Human Sera.Semantic proximity Read ↗

A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species.Semantic proximity Read ↗

Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain.Semantic proximity Read ↗

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition.Semantic proximity Read ↗

Rapid cloning of HLA class I cDNAs by locus specific PCR.Semantic proximity Read ↗

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.Semantic proximity Read ↗

Expression of I-A alpha k and allelic restriction on A alpha/A beta pairing in transgenic mice.Semantic proximity Read ↗

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.Semantic proximity Read ↗

HLA-DQ polymorphisms are highly selective for peptide binding interactions.Semantic proximity Read ↗

Differential expression of insulin-dependent diabetes mellitus-associated HLA-DQA1 alleles in vivo.Semantic proximity Read ↗

Cell surface expression level variation between two common Human Leukocyte Antigen alleles, HLA-A2 and HLA-B8, is dependent on the structure of the C terminal part of the alpha 2 and the alpha 3 domains.Semantic proximity Read ↗

The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.