Article

HLA-DQ monomer-based enrichment of alloreactive CD4 T cells

2025-06-02

Abstract excerpt

Donor-specific T cell responses, particularly against human leukocyte antigen (HLA)-DQ antigens, are critical in transplant immunology as they influence graft survival and rejection. This study investigated HLA-DQ-specific CD4 T cell responses in naive individuals using HLA-DQ monomers, representing common donor HLA-DQ antigens (DQ2.5, DQ5, DQ6, DQ8), as defined alloantigen sources to enrich and detect HLA-DQ-spec...

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Literature Corpus work: 7d9e420b-fc13-5ba3-9861-50fdc034b6bc
DOI: 10.1101/2025.05.30.656890

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