Article
Five commercially-available antibodies react differentially with allelic forms of human HLA-DR beta chain.
Molecular immunology - 1 Dec 2022
Houtman Miranda, Dzebisashvili Anna, Dubnovitsky Anatoly, Kozhukh Genadiy, Rönnblom Lars, Klareskog Lars, Malmström Vivianne, Padyukov Leonid
Abstract excerpt
Allelic variants of HLA-DRB1 have been associated with a variety of autoimmune and infectious diseases. Although the precise molecular mechanisms by which HLA-DRB1 alleles predispose to a particular disease are currently unclear, it has been shown that mRNA expression levels of HLA-DRB1 are dependent on the different alleles. We aimed to measure HLA-DR beta chain levels in peripheral blood mononuclear cells of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
