Article
A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species.
The Journal of biological chemistry - 10 Jan 2014
Temme Sebastian, Zacharias Martin, Neumann Jürgen, Wohlfromm Sebastian, König Angelika, Temme Nadine, Springer Sebastian, Trowsdale John, Koch Norbert
Abstract excerpt
HLA class II α and β chains form receptors for antigen presentation to CD4(+) T cells. Numerous pairings of class II α and β subunits from the wide range of haplotypes and isotypes may form, but most of these combinations, in particular those produced by isotype mixing, yielded mismatched dimers. It is unclear how selection of functional receptors is achieved. At the atomic level, it is not known which...
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