Article
Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.
Cellular and molecular life sciences : CMLS - 27 Jan 2024
Su Chao, Liu Mingxia, Yao Xuyang, Hao Wei, Ma Jinzheng, Ren Yuanyuan, Gao Xingjie, Xin Lingbiao, Ge Lin, Yu Ying, Wei Minxin, Yang Jie
Abstract excerpt
BACKGROUND: Vascular smooth muscle cell (VSMC) proliferation is the leading cause of vascular stenosis or restenosis. Therefore, investigating the molecular mechanisms and pivotal regulators of the proliferative VSMC phenotype is imperative for precisely preventing neointimal hyperplasia in vascular disease. METHODS: Wire-induced vascular injury and aortic culture models were used to detect the expression of...
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