Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytoskeletal-related genes function as checkpoints for the maintenance of VSMC contractile phenotype and prevent pathological remodeling in arterial diseases.

Journal of advanced research - 1 Mar 2026

Liu Yunchang, Zeng Liping, Cai Qi, Zeng Yunfei, Zheng Shuo, Gong Xue, Zhou Lu, Tian Miao, Chen Lianglong, Wu Gengze, Zeng Chunyu

Abstract excerpt

INTRODUCTION: Arterial pathological remodeling, central to arterial diseases including atherosclerosis and aortic aneurysms, is characterized by vascular smooth muscle cell (VSMC) phenotypic switching with concomitant loss of contractile markers. Uncovering the molecular changes initiating phenotypic transition may advance the understanding of vascular pathogenesis and provide new therapeutic strategies....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeleton

Share to Disease Models, Animal

Share to Muscle Contraction

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 40516911
DOI: 10.1016/j.jare.2025.05.065
PMCID: PMC12957834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytoskeletal-related genes function as checkpoints for the maintenance of VSMC contractile phenotype and prevent pathological remodeling in arterial diseases.PMID 40516911Read ↗

How vascular smooth muscle cell phenotype switching contributes to vascular disease.Semantic proximity Read ↗

Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4).Semantic proximity Read ↗

Chromatin Remodeling in VSMC Phenotype Switching During Vascular Remodeling: From Mechanism to Therapeutic Potential.Semantic proximity Read ↗

Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm.Semantic proximity Read ↗

Elucidating VSMC phenotypic transition mechanisms to bridge insights into cardiovascular disease implicationsSemantic proximity Read ↗

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity.Semantic proximity Read ↗

Smooth Muscle Heterogeneity and Plasticity in Health and Aortic Aneurysmal Disease.Semantic proximity Read ↗

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis.Semantic proximity Read ↗

Dysregulated smooth muscle cell proliferation and gene expression underlie ACTA2 variant-associated aortopathy.Semantic proximity Read ↗

Integrative analysis of single-cell transcriptomics and genetic associations identify cell states associated with vascular disease.Semantic proximity Read ↗

Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases.Semantic proximity Read ↗

PDIA1 acts as master organizer of NOX1/NOX4 balance and phenotype response in vascular smooth muscle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.