Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling.

Nature communications - 13 Aug 2024

Xu Yue, Zhang Haifeng, Chen Yuxin, Pober Jordan S, Zhou Min, Zhou Jenny Huanjiao, Min Wang

Abstract excerpt

Serum response factor (SRF) controls gene transcription in vascular smooth muscle cells (VSMCs) and regulates VSMC phenotypic switch from a contractile to a synthetic state, which plays a key role in the pathogenesis of cardiovascular diseases (CVD). It is not known how post-translational SUMOylation regulates the SRF activity in CVD. Here we show that Senp1 deficiency in VSMCs increased SUMOylated SRF and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine Endopeptidases
Share to ets-Domain Protein Elk-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Neointima

Share to Serum Response Factor

Share to Sumoylation

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 39134547
DOI: 10.1038/s41467-024-51350-5
PMCID: PMC11319592

Genes

SRF
ELK1
SENP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling.PMID 39134547Read ↗

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodelingSemantic proximity Read ↗

Sentrin-specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis.Semantic proximity Read ↗

Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.Semantic proximity Read ↗

Deficiency of protein inhibitor of activated STAT3 exacerbates atherosclerosis by modulating VSMC phenotypic switching.Semantic proximity Read ↗

HERP1 Inhibits Myocardin-Induced Vascular Smooth Muscle Cell Differentiation by Interfering With SRF Binding to CArG BoxSemantic proximity Read ↗

SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with MyocardinSemantic proximity Read ↗

NEXN regulates vascular smooth muscle cell phenotypic switching and neointimal hyperplasia.Semantic proximity Read ↗

Smooth muscle cell phenotypic modulation during atherosclerosis.Semantic proximity Read ↗

A Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor.Semantic proximity Read ↗

UFM1 suppresses VSMCs phenotypic switching and attenuates atherosclerosis by inhibiting AKT phosphorylation.Semantic proximity Read ↗

Knockdown of Herp alleviates hyperhomocysteinemia mediated atherosclerosis through the inhibition of vascular smooth muscle cell phenotype switching.Semantic proximity Read ↗

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.