Article

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling

2023-05-22

Abstract excerpt

<title>Abstract</title> <p>Serum response factor (SRF) controls gene transcription in vascular smooth muscle cells (VSMCs) and regulates VSMC phenotypic switch from a contractile to a synthetic state, which plays a key role in the pathogenesis of cardiovascular diseases (CVD). SRF activity is regulated by its associated cofactors. However, it is not known how post-translational SUMOylation regulates the SRF activ...

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Literature Corpus work: 72e5ace2-f256-5fdc-b996-2d33e8b2247d
DOI: 10.21203/rs.3.rs-2922216/v1

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