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Article

HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress.

Molecular and cellular biochemistry - 1 Nov 2024

Wang Linli, Ren Zhitao, Wu Lin, Zhang Ximei, Wang Min, Niu Haiming, He Xuemin, Wang Heting, Chen Yanming, Shi Guojun, Qian Xiaoxian

Abstract excerpt

Phenotypic change of vascular smooth muscle cells (VSMCs) is the main contributor of vascular pathological remodeling in atherosclerosis. The endoplasmic reticulum (ER) is critical for maintaining VSMC function through elimination of misfolded proteins that impair VSMC cellular function. ER-associated degradation (ERAD) is an ER-mediated process that controls protein quality by clearing misfolded proteins. One of...

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PMID: 38145449
DOI: 10.1007/s11010-023-04902-0

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