Article
NEXN regulates vascular smooth muscle cell phenotypic switching and neointimal hyperplasia.
JCI insight - 8 Jul 2025
Lin Zexuan, Wang Chaojie, Wen Zhuohua, Cai Zhaohui, Guo Wenjie, Feng Xin, Huang Zengyan, Zou Rongjun, Fan Xiaoping, Liu Canzhao, Yang Hanyan
Abstract excerpt
Vascular smooth muscle cells (VSMCs) exhibit substantial heterogeneity and plasticity, enabling them to switch between contractile and synthetic states, which is crucial for vascular remodeling. Nexilin (NEXN) has been identified as a high-confidence gene associated with dilated cardiomyopathy. Existing evidence indicates NEXN is involved in phenotypic switching of VSMCs. However, a comprehensive understanding of...
Read the complete abstract on PubMedTopics
- Animals
- Muscle, Smooth, Vascular
- Mice
- Neointima
- Hyperplasia
- Myocytes, Smooth Muscle