Article
How vascular smooth muscle cell phenotype switching contributes to vascular disease.
Cell communication and signaling : CCS - 21 Nov 2022
Cao Genmao, Xuan Xuezhen, Hu Jie, Zhang Ruijing, Jin Haijiang, Dong Honglin
Abstract excerpt
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a high migration and proliferation capacity for repairing vascular injury. In recent years, largely owing to rapid technological advances in single-cell sequencing...
Topics
- Humans
- Muscle, Smooth, Vascular
- Vascular System Injuries
- Cell Proliferation
- Phenotype
- Atherosclerosis