Article
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity.
Cellular signalling - 1 Dec 2018
Frismantiene Agne, Philippova Maria, Erne Paul, Resink Therese J
Abstract excerpt
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike many other mature cell types in the adult body, VSMC do not terminally differentiate but retain a remarkable plasticity. Fully differentiated medial VSMCs of mature vessels maintain quiescence and express a range of genes and proteins important for contraction/dilation, which allows them to control systemic and local pressure...
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