Article
Early and multiple origins of metastatic lineages within primary tumors.
Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2016
Zhao Zi-Ming, Zhao Bixiao, Bai Yalai, Iamarino Atila, Gaffney Stephen G, Schlessinger Joseph, Lifton Richard P, Rimm David L, Townsend Jeffrey P
Abstract excerpt
Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such as the divergence times and genetic clonality of metastatic lineages. To address these challenges, we performed tumor phylogenetics using molecular evolutionary models, reconstructed ancestral states of somatic mutations, and inferred cancer chronograms to...
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