Article
Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.
Scientific reports - 6 Dec 2017
O'Hagan Kyle L, Miller Stephen D, Phee Hyewon
Abstract excerpt
Foxp3, a key transcription factor that drives lineage differentiation of regulatory T cells (Tregs), was thought to imprint a unique and irreversible genetic signature within Tregs. Recent evidence, however, suggests that loss or attenuation of Foxp3 expression can cause Tregs to de-differentiate into effector T cells capable of producing proinflammatory cytokines. Herein, we report that the signaling kinase,...
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