Article

Defects in CD8 <sup>+</sup> T cell suppression by Foxp3-ΔE2 expressing regulatory T cells

2026-04-23

Abstract excerpt

<h4> Abstract </h4> Regulatory T cells (Tregs) prevent autoimmunity through suppressive functions largely programmed by the transcription factor FOXP3. Healthy humans express approximately equivalent levels of two major alternatively spliced isoforms of FOXP3: a full-length version containing all coding exons (FOXP3-FL) and a version lacking exon 2 (FOXP3-ΔE2). However, sole FOXP3-ΔE2 expression causes lethal IP...

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Literature Corpus work: 8cdfaeba-feb6-5f90-b1b5-db06f8cd5674
DOI: 10.64898/2026.04.20.719728

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