Article
Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample.
Acta neuropathologica communications - 19 Dec 2023
Paradela Regina Silva, Justo Alberto Fernando Oliveira, Paes Vítor Ribeiro, Leite Renata E P, Pasqualucci Carlos A, Grinberg Lea T, Naslavsky Michel Satya, Zatz Mayana, Nitrini Ricardo, Jacob-Filho Wilson, Suemoto Claudia Kimie
Abstract excerpt
BACKGROUND: Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer's disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there is limited evidence available from diverse populations, as APOE associations with dementia seem to differ by race. Therefore, we aimed to evaluate the pathways linking APOE-ε4 to cognitive abilities...
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