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Article

Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Xu Wei-Li, Caracciolo Barbara, Wang Hui-Xin, Santoni Giola, Winblad Bengt, Fratiglioni Laura

Abstract excerpt

The impact of APOE ε4 on mild cognitive impairment (MCI) and its progression to dementia remain controversial. We aimed to examine the association of APOE ε4 with MCI, and to verify the hypothesis that ε4 accelerates progression from MCI to dementia. In the Kungsholmen project, 756 cognitively healthy participants and 212 people with MCI aged ≥75 years were identified at baseline. Amnestic MCI (aMCI) and other...

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Source

Identifiers

PMID: 23247007
DOI: 10.3233/JAD-2012-121369

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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