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Article

APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.

Neurology - 12 Jun 2018

Oveisgharan Shahram, Buchman Aron S, Yu Lei, Farfel Jose, Hachinski Vladimir, Gaiteri Chris, De Jager Philip L, Schneider Julie A, Bennett David A

Abstract excerpt

OBJECTIVE: To examine the association of the APOE ε2ε4 genotype with incident Alzheimer disease (AD), mild cognitive impairment (MCI), cognitive decline, and AD pathology in older adults. METHODS: We used data from 2,151 older adults of European ancestry who were free of dementia at baseline and underwent structured annual clinical evaluation in a longitudinal study for incident AD and MCI, and cognitive decline....

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Source

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Identifiers

PMID: 29752306
DOI: 10.1212/WNL.0000000000005677
PMCID: PMC5996834

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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