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Article

AD and non-AD mediators of the pathway between the APOE genotype and cognition.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2023

Nichols Emma, Brickman Adam M, Casaletto Kaitlin B, Dams-O'Connor Kristen, George Kristen M, Kumar Raj G, Palta Priya, Rabin Jennifer S, Satizabal Claudia L, Schneider Julie, Pa Judy, La Joie Renaud

Abstract excerpt

INTRODUCTION: The apolipoprotein E (APOE) genotype is a driver of cognitive decline and dementia. We used causal mediation methods to characterize pathways linking the APOE genotype to late-life cognition through Alzheimer's disease (AD) and non-AD neuropathologies. METHODS: We analyzed autopsy data from 1671 individuals from the Religious Orders Study, Memory and Aging Project, and Minority Aging Research Study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36516004
DOI: 10.1002/alz.12885
PMCID: PMC10264550

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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