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Article

APOEε2 is associated with milder clinical and pathological Alzheimer disease.

Annals of neurology - 1 Jun 2015

Serrano-Pozo Alberto, Qian Jing, Monsell Sarah E, Betensky Rebecca A, Hyman Bradley T

Abstract excerpt

OBJECTIVE: The Alzheimer disease (AD) APOEε4 risk allele associates with an earlier age at onset and increased amyloid-β deposition, whereas the protective APOEε2 allele delays the onset and appears to prevent amyloid-β deposition. Yet the clinical and pathological effects of APOEε2 remain uncertain because of its relative rarity. We investigated the effects of APOEε2 and ε4 alleles on AD pathology and cognition...

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Source

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Identifiers

PMID: 25623662
DOI: 10.1002/ana.24369
PMCID: PMC4447539

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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