Article
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Developmental cell - 18 Dec 2023
Funk Maja C, Gleixner Jan G, Heigwer Florian, Vonficht Dominik, Valentini Erica, Aydin Zeynep, Tonin Elena, Del Prete Stefania, Mahara Sylvia, Throm Yannick, Hetzer Jenny, Heide Danijela, Stegle Oliver, Odom Duncan T, Feldmann Angelika, Haas Simon, Heikenwalder Mathias, Boutros Michael
Abstract excerpt
Low-grade chronic inflammation is a hallmark of ageing, associated with impaired tissue function and disease development. However, how cell-intrinsic and -extrinsic factors collectively establish this phenotype, termed inflammaging, remains poorly understood. We addressed this question in the mouse intestinal epithelium, using mouse organoid cultures to dissect stem cell-intrinsic and -extrinsic sources of...
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