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Innate immunity of the gut epithelium: Blowing in the WNT?

10 Jun 2025

Abstract excerpt

Intestinal epithelial cells need to be able to launch a quick and adequate immune response against pathogens, while tolerating commensals. This delicate balance requires a tight control over the activation of the NFκB and Interferon pathways to prevent chronic inflammation. Simultaneously, intestinal stem cell maintenance and differentiation are strictly regulated by the WNT/β-catenin and Bone Morphogenetic...

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PMID: 40505889
DOI: 10.1016/j.mucimm.2025.06.004

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