Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan

25 Oct 2022

Abstract excerpt

Why biological age is a major risk factor for many of the most important human diseases remains mysterious. We know that as organisms age, stem cell pools are exhausted while senescent cells progressively accumulate. Independently, induction of pluripotency via expression of Yamanaka factors (Oct4, Klf4, Sox2, c-Myc; OKSM) and clearance of senescent cells have each been shown to ameliorate cellular and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics, Aging, and Longevity in Model Organisms
Share to Pluripotent Stem Cells Research
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36287172
DOI: 10.18632/aging.204347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespanPMID 36287172Read ↗

Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend LifespanSemantic proximity Read ↗

When stem cells grow old: phenotypes and mechanisms of stem cell agingSemantic proximity Read ↗

Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identitySemantic proximity Read ↗

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseasesSemantic proximity Read ↗

Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)Semantic proximity Read ↗

The interplay of cellular senescence and reprogramming shapes the biological landscape of aging and cancer revealing novel therapeutic avenuesSemantic proximity Read ↗

Adult Stem Cells and Diseases of AgingSemantic proximity Read ↗

Stem cells and anti-aging genes: double-edged sword—do the same job of life extensionSemantic proximity Read ↗

Manifestations and mechanisms of stem cell aging.Semantic proximity Read ↗

Why stem/progenitor cells lose their regenerative potentialSemantic proximity Read ↗

Genetic and Epigenetic Interactions Involved in Senescence of Stem CellsSemantic proximity Read ↗

Toward a Unified Theory of Aging and RegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.