Article

Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in Pouchitis

2025-03-20

Abstract excerpt

<h4>SUMMARY</h4> Intestinal stem cells (ISCs) mediate the continuous renewal of the epithelium during homeostasis and recovery from injury. To investigate the molecular impact of inflammation on human ISCs, we established an organoid model derived from individuals with pouchitis, a form of inflammatory bowel disease that develops in an organ generated from ileal pouch-anal anastomosis (IPAA) surgery. Compared wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25db3150-b6ab-5f2e-b9ca-9ed22d09272a
DOI: 10.1101/2025.03.19.644201

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in PouchitisDOI 10.1101/2025.03.19.644201Read

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn’s diseaseSemantic proximity Read

Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of InflammationSemantic proximity Read

Intestinal Stem and Progenitor Cells Exhibit Distinct Adaptive Responses to Inflammatory Stress in IBDSemantic proximity Read

Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patientsSemantic proximity Read

Celiac disease patient derived iPSC–small intestinal epithelial cells are more persistent under cytokine stimuli than healthy control cellsSemantic proximity Read

Regenerative Intestinal Stem Cells Induced by Acute and Chronic Injury: The Saving Grace of the Epithelium?Semantic proximity Read

Establishment of intestinal organoid cultures modeling injury-associated epithelial regenerationSemantic proximity Read

Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.Semantic proximity Read

Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal OrganoidsSemantic proximity Read

Single Cell Integration Characterises Metaplasia in Inflammatory Intestinal DiseasesSemantic proximity Read

The therapeutic potential of mesenchymal stem cells in intestinal diseases: from mechanisms to clinical translationSemantic proximity Read

Bacterial infection drives trained immunity through epigenetic remodeling of epithelial stem cellsSemantic proximity Read