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Article

Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells.

Aging - 29 Aug 2017

Moorefield Emily C, Andres Sarah F, Blue R Eric, Van Landeghem Laurianne, Mah Amanda T, Santoro M Agostina, Ding Shengli

Abstract excerpt

Intestinal epithelial stem cells (IESCs) are critical to maintain intestinal epithelial function and homeostasis. We tested the hypothesis that aging promotes IESC dysfunction using old (18-22 months) and young (2-4 month) Sox9-EGFP IESC reporter mice. Different levels of Sox9-EGFP permit analyses of active IESC (Sox9-EGFPLow), activatable reserve IESC and enteroendocrine cells (Sox9-EGFPHigh), Sox9-EGFPSublow...

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Enterocytes
Goblet Cells
Jejunum
Lac Operon
Paneth Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

SOX9 Transcription Factor

Spheroids, Cellular

Tissue Culture Techniques

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Identifiers

PMID: 28854151
DOI: 10.18632/aging.101279
PMCID: PMC5611984

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