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Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

1 Mar 2017

Abstract excerpt

Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number, and cell composition upon aging. Second, we identify a decline in the regenerative capacity of ISCs upon aging because of a decline in canonical Wnt signaling in ISCs. Changes in expression of Wnts are found in stem cells...

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PMID: 28297666
DOI: 10.1016/j.celrep.2017.02.056

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