Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan

Abstract excerpt

<h4>ABSTRACT</h4> Why biological age is a major risk factor for many of the most important human diseases remains mysterious. We know that as organisms age, stem cell pools are exhausted while senescent cells progressively accumulate. Independently, induction of pluripotency via expression of Yamanaka factors ( Oct4, Klf4, Sox2, c-Myc; OKSM) and clearance of senescent cells have each been shown to ameliorate ce...

Topics

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• Cellular Senescence
• Diet
• Genetics, Aging, and Longevity in Model Organisms
• Metabolome
• Phenotype
• Pluripotent Stem Cells Research
• Stem Cell Transplantation
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

aac9956d-620c-5f47-a66e-8f60239d0f32

DOI

10.1101/2022.04.21.488994